CALL FOR PAPERS Cardiovascular and Cerebrovascular Aging–New Mechanisms and Insights Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction
نویسندگان
چکیده
Andriy Yabluchanskiy, Yonggang Ma, Ying Ann Chiao, Elizabeth F. Lopez, Andrew P. Voorhees, Hiroe Toba, Michael E. Hall, Hai-Chao Han, Merry L. Lindsey, and Yu-Fang Jin San Antonio Cardiovascular Proteomics Center, San Antonio, Texas; Department of Physiology and Biophysics, Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, Mississippi; Department of Pathology, University of Washington, Seattle, Washington; Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, Texas; Division of Pathological Sciences, Department of Clinical Pharmacology, Kyoto Pharmaceutical University, Kyoto, Japan; Division of Cardiology, University of Mississippi Medical Center; Jackson, Mississippi; Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center; Jackson, Mississippi; and Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas
منابع مشابه
Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction.
Aging is linked to increased matrix metalloproteinase-9 (MMP-9) expression and extracellular matrix turnover, as well as a decline in function of the left ventricle (LV). Previously, we demonstrated that C57BL/6J wild-type (WT) mice > 18 mo of age show impaired diastolic function, which was attenuated by MMP-9 deletion. To evaluate mechanisms that initiate the development of cardiac dysfunction...
متن کاملCALL FOR PAPERS Cardiovascular and Cerebrovascular Aging—New Mechanisms and Insights Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction
Julien Maizel, Sandhya Xavier, Jun Chen, Chi Hua Sarah Lin, Radovan Vasko, and Michael S. Goligorsky Medical Intensive Care Unit, Department of Nephrology and INSERM U-1088, University of Picardie, Amiens, France; Department of Nephrology and Rheumatology, University Medical Center, Gottingen, Germany; and Department of Medicine, Renal Research Institute, New York Medical College, Valhalla, New...
متن کاملOxidative Stress, Inflammation, and Vascular Aging in Hypertension.
Age-related decline in function is a physiological phenomenon occurring in all organ systems. However, acceleration and early occurrence of this process are observed in cardiovascular pathologies, including hypertension. In the vascular system, this is characterized by progressive pathological remodeling with stiffening, typically associated with extracellular matrix (ECM) alterations in collag...
متن کاملTransgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis.
Advancing age is an independent risk factor for cardiovascular disease. Matrix metalloproteinase-9 (MMP-9) is secreted by macrophages and robustly increases in the left ventricle (LV) with age. The present study investigated the effect of MMP-9 overexpression in macrophages on cardiac aging. We compared 16- to 21-mo-old C57BL/6J wild-type (WT) and transgenic (TG) male and female mice (n = 15-20...
متن کاملPhysical activity and cardiovascular aging: Physiological and molecular insights
Aging is associated with significant changes in both cardiac and vascular structure and function that lower the threshold for clinical signs and symptoms, making older people more susceptible to cardiovascular diseases, morbidity and mortality. Understanding of age-related cardiovascular changes is necessary for effective and efficient prevention and treatment of cardiovascular disease in older...
متن کامل